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KMID : 0381120180400020199
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Genes and Genomics
2018 Volume.40 No. 2 p.199 ~ p.206
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Association analysis of the SNP (rs345476947) in the FUT2 gene with the production and reproductive traits in pigs
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Wang Haifei
Wu Sen
Wu Jiayun
Sun Shouyong
Wu Shenglong
Bao Wenbin
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Abstract
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The FUT2 gene was considered as an important candidate for pathogenic infections, while the potential associations between this gene and the production and reproductive traits of pigs have not been explored. In this study, we detected the genetic variants of porcine FUT2 gene and analyzed the associations of the polymorphisms with FUT2 mRNA expression and production and reproductive traits (age at 100 kg, backfat thickness at 100 kg, eye muscle thickness, the number of newborn piglets, the number of weaned piglets, and birth weight) in 100 Large White sows. One single nucleotide polymorphism (SNP) (rs345476947, C→T) in the intron of FUT2 and three genotypes (TT, CT and CC) were determined. Association analysis revealed significant associations between this SNP with the number of newborn piglets and weaned piglets. Furthermore, individuals with the TT genotype had significantly higher numbers of newborn piglets and weaned piglets than those with the CC genotype (P?
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KEYWORD
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Pig, FUT2 gene, SNP, Production and reproductive traits
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